Internal Medicine: Open Access
Open Access
ISSN: 2165-8048
+44 1300 500008
ISSN: 2165-8048
+44 1300 500008
Olaoluwa Ruth Obisesan, Abolanle Saheed Adekunle, Sabu Thomas, John Adekunle Oyedele Oyekunle and Praveen Govindh
Obafemi Awolowo University, Nigeria
Mahatma Gandhi University, India
Scientific Tracks Abstracts: Intern Med
Plasmodium falciparum (malaria parasite) catabolize hemoglobin to produce toxic-free heme which then, biocrystalize to hemozoin, also known as malaria pigment. Hemozoin and its synthetic compound (�²-hematin) is a good biomarker for diagnosis of early malarial infection in patients. This study explores the catalytic degradation of �²-hematin with metal oxide (MO) nanoparticles using UV-Vis Spectroscopy method. Metal oxide nanoparticles, copper oxide (CuO), aluminium oxide (Al2O3) and iron (II, III) oxide (Fe3O4) were synthesized using both chemical and microwave methods while �²-hematin was synthesized from hemin chloride. The synthesized MO nanoparticles were characterized using scanning electron microscope, x-ray diffraction spectroscopy, UV-visible spectroscopy, etc. The catalytic degradation of �²-hematin was studied by reacting 50 mL of 50 mg/L prepared �²-hematin with 5-25 mg of each synthesized metal oxide nanoparticles. It was observed that all the metal oxides used successfully degraded �²-hematin, while iron (II) oxide nanoparticles displayed the best catalytic properties followed by copper oxide and aluminium oxide nanoparticles. 25 mg microwave synthesized iron (II) oxide nanoparticles degraded �²-hematin completely. It can be concluded that metal oxide nanoparticles are potential catalyst for fabrication of electrochemical sensor for diagnostic purpose for malaria pigment and also they can also be use in drug formulation in targeting hemozoin
Olaoluwa Ruth Obisesan is undergoing her PhD Program in Obafemi Awolowo University, Ile-Ife, Nigeria. She has published five papers in reputed journals.