Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Shahd Talhouni
University of Nottingham, UK
Posters & Accepted Abstracts: J Clin Cell Immunol
Background: CD103 is expressed in several immune cell types such as dendritic cells, natural killer (NK) cells and different subset of T cells (CD8, CD4 and Treg). CD103 on tumour-specific infiltrating lymphocytes interact with E-cadherin on cancer cells which will locate and facilitate cytotoxic granule delivery into target cells. This integrin is considered as one of the main markers of non-recirculating tissue resident memory (TRM) T cells. A significant prognostic value of CD103+ TILs was shown in breast cancer, lung cancer and ovarian cancer. In this study we will investigate the association between CD103 TILs and the overall survival of colorectal patients. Methods: IHC staining of 227 tissue microarray (TMA) of colorectal cancer patients using a monoclonal antibody to CD103 to examine the prognostic value of CD103 tumor infiltrating lymphocytes (TILs) in colorectal cancer patients. Results: CD103 TILs were present in both colon and rectal cancer patients. However, intraepithelial CD103 was associated with better overall survival in right colon cancer patients (p=0.01) in comparison to left sided colon and rectal cancer patients (p=0.665 and 0.818, respectively). The correlation of CD103 and other T cells biomarkers (CD3 and CD8) was not significantly indicating the possibility that CD103 is not uniquely expressed by T lymphocytes. Conclusion: Intraepithelial CD103 TILs but not intrastromal are associated with better survival in colon cancer, especially right sided cancer patients.