Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
+44 1300 500008
ISSN: 2376-0419
+44 1300 500008
Ki Yong Lee
Korea University, Republic of Korea
Posters & Accepted Abstracts: J Pharma Care Health Sys
Five new alkyl phloroglucinol derivatives, characterized as (Z)-15-hydroxy-1-(2,4,6-trihydroxyphenyl)-9-octadecen-1-one (named trichocarpol A, 1), (Z)-15-hydroxy-1-(2,6-dihydroxy-4-methoxyphenyl)-9-octadecen-1-one (named trichocarpol B, 2), (Z)-17- hydroxy-1-(2,4,6-trihydroxyphenyl)-9-octadecen-1-one (named trichocarpol C, 3), (Z)-18-hydroxy-1-(2,4,6-trihydroxyphenyl)- 9-octadecen-1-one (named trichocarpol D, 4), and (9Z,12Z)-18-hydroxy-1-(2,4,6-trihydroxyphenyl)-9,12-octadecadien-1-one (named trichocarpol E, 5) were isolated from the roots of Rhus trichocarpa together with a known compound, 4-(2,6-dihydroxy-4- methoxyphenyl)-4-oxobutanoic acid (6). The cytotoxic activity of compounds 1ΓΆΒ?Β?6 was evaluated in human gastric adenocarcinoma AGS cells and compounds 1ΓΆΒ?Β?5 showed significant cytotoxicity. Our results suggest that R. trichocarpa, especially the alkyl phloroglucinol derivatives in it, is a good source of natural agents for the treatment of gastric cancer.
Ki Yong Lee has completed her PhD from Seoul National University and Postdoctoral studies from Michigan State University. She is the Associate Professor of College of Pharmacy, Korea University. She has published more than 66 papers in reputed journals.
Email: kylee11@korea.ac.kr