Organic Chemistry: Current Research
Open Access
ISSN: 2161-0401
+44 1478 350008
ISSN: 2161-0401
+44 1478 350008
Kerru Nagaraju and Parvesh Singh
University of KwaZulu-Natal, South Africa
Posters & Accepted Abstracts: Organic Chem Curr Res
Synthesis of novel fused heterocycles is an imperative task for heterocyclic chemists from various points of view for the development of compounds of pharmacological and industrial importance. Consequently, the thienopyrimidine ring system constitutes an attractive target for the design of new antioxidant drugs through wide structure variations. This class of compounds has also found wide applications in the design and discovery of novel bioactive molecules and drugs. Recently, thienopyrimidine derivatives play an essential role in several biological processes and have considerable chemical and pharmacological activities. Many of thienopyrimidine derivatives were found to possess a variety of pronounced activities such as antiviral as well as antidiabetic activities. Moreover, some of triazolo thienopyrimidines show significant antifungal and antibacterial activities whereas some exhibited anti-inflammatory and anticancer activities. However, the click chemistry is an excellent approach for regioselective synthesis of 1, 2, 3-triazole ring system in presence of various functional groups. 1, 2, 3-triazole has been extensively studied owing to its importance in industrially interesting materials, such as dyes, anticorrosive agents, photo stabilizers, photographic materials and agrochemicals. Although, 1, 2, 3-triazole compounds showing various biological activities including anti-HIV, anti-bacterial, antiallergic, anticonvulsant, �²-lactamase inhibitory and antituberculosis activities. We therefore found it interesting to design new molecules within the scope of synthetic procedure using thienopyrimidine scaffold followed by suitable modification to generate diversified compounds for antioxidant activity. In this study, we oppressed click chemistry for the synthesis of diversified thienopyrimidine derivatives. In view of these observations and in continuation to our work on thienopyrimidine chemistry we synthesized some new compounds containing 1, 2, 3-triazolo thienopyrimidine moieties by copper catalyzed cyclo addition of alkynyl thienopyrimidinone with various substituted aryl azides in the presence of CuSO4 and sodium ascorbate in THF/H2O (1:1), and tested for their antioxidant activity.
Email: nagarajukerru@gmail.com