Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-77-2385-9429
ISSN: 2157-7609
+44-77-2385-9429
Fazliddin Jalilov
Ministry of Health of the Republic of Uzbekistan, Uzbekistan
Posters-Accepted Abstracts: J Drug Metab Toxicol
Introduction: In Uzbekistan, sertraline and venlafaxine acquired extraordinary importance in the drug monitoring, chemicaltoxicological and forensic chemical examination. The reason for it is frequent incidents of acute and chronic poisoning by the representatives of these medicinal agents. The Aripov Institute of Electronics developed and made the indicator â??Iskovich-1â? for the detection and analysis of trace amounts of drugs and other abused medicinal preparations in usersâ?? urine, blood and cadaveric materials by means of the thermal desorption surface ionization spectroscopy method (ТDSIS). The aim of the research is to develop the isolation method of sertraline and venlafaxine from biological material. Methods: For detection of energizers by a method of thermal desorption surface ionization spectroscopy the analysis has been carried out in the following conditions: The emitter oxidized the molybdenum which has iridium in it; voltage of the emitter-405 V; emitter temperature-390-420?°Ð¡, temperature of evaporation from 20 to 505?°Ð¡; air stream-50 L/hour (voltage of the compressor 12 V). Results: The thermal desorption range sertraline has characteristic peak at ~131?±15oС to ~190?±15oС (sensitivity 0.3 mkg/mL) and venlafaxine has characteristic peaks at ~110?±15?ºÐ¡ to ~186?±20?ºÐ¡ (sensitivity 0.5 mkg/mL). Also calibration curve for determination of the quantity of isolated from biological material was drawn. Sertraline in the case of a linear dynamic range of determination was 1.0-100 mkg/mL and venlafaxine10-200 mkg/mL. Conclusions: The received spectra testify that by means of the TDSIS method of analysis it is possible to define authentically sertraline and venlafaxine in medicinal products and biological objects.