Journal of Clinical and Experimental Ophthalmology
Open Access

Flammer-syndrome as one of the risk factors for GON

5^th International Conference on Clinical & Experimental Ophthalmology

August 04-06, 2015 Valencia, Spain

Maneli Mozaffarieh

Scientific Tracks Abstracts: J Clin Exp Ophthalmol

Abstract :

Increased intraocular pressure (IOP) is a major risk factor for glaucomatous damage and reducing IOP improves prognosis.
Nevertheless, there is little doubt that other risk factors besides IOP such as unstable ocular perfusion are involved. Blood flow is
unstable if either the IOP fluctuates at a high level (or blood pressure fluctuates at a low level) or if the autoregulation of blood flow
disturbed. A common cause for a disturbed OBF autoregulation is a primary vascular dysregulation (PVD) frequently observed
in normal tension glaucoma patients. An unstable blood flow leads to recurrent mild reperfusion injury (chronic oxidative stress)
affecting particularly the mitochondria of the optic nerve head. OBF regulation can be improved by magnesium, calcium channel
blockers as well as with carbonic anhydrase inhibitors.

Biography :

Maneli Mozaffarieh is a Glaucoma Specialist working at the University of Basel, Department of Ophthalmology. The focus of her research is on ocular blood flow.