Journal of Developing Drugs
Open Access
ISSN: 2329-6631
+44 1478 350008
ISSN: 2329-6631
+44 1478 350008
Ahmed M El-Saghier
Sohag University, Egypt
Posters & Accepted Abstracts: J Develop Drugs
A several number of triazole heterocyclic containing amino acid derivatives were prepared using green conditions. These method was very interesting due to inexpensive, efficient, nontoxic and ecofriendly used for synthesis of some new triazole derivatives in aqueous media by the reaction of salicylic acid or 2-hydroxy acetophenone with substituted amino acids and thiosemicarbazide in multicomponent reaction. The operational simplicity, high yield achieved in short reaction time and green aspects by avoiding toxic catalyst which uphold the motive of green chemistry are major benefits that meet the requirements of green production including saving energy and high efficiency. The new derivatives allowed to reacts with different reagent to afford new heterocyclic compound such as pyrimidotriazole, N-substituted triazoles, imidatriazoleone and benzoxazintrozole derivatives. As well as, the present work involved the reaction of some newly triazole derivatives as starting material, for example compound 4, to react with various reagents in multicomponent reactions to afford new heterocyclic compounds such as Benzothiazopinotriazole, Pyrimidotriazole and Mannish bases of triazole. Azo Dyes are synthesized with different amines in presence of sodium nitrate and hydrochloric acid. Finally, it is important to illustrate that a large number of synthesized compounds contained Nitrogen Bridge-Head which had an interested biological activity. Some of synthesized compounds screened potent as Antileishmanial agents. All the synthesized compounds characterized by IR, 1HNMR, 13CNMR elemental analysis and mass spectra.
Email: El_saghier@yahoo.com