Journal of Developing Drugs
Open Access

Green tea polyphenols for the protection against isoprenaline-induced myocardial infarction in experimental hyperhomocysteinemia rats

Joint Event on 8^th International Conference and Exhibition on Pharmaceutical Regulatory Affairs and IPR & 8^th International Conference and Exhibition on Pharma Audit, GMP, GCP & Quality Control

June 08-09, 2018 | Philadelphia, USA

Azza Hafiz EL Medany and Jamila Hafiz El Medany

Alexandria University, Egypt

Posters & Accepted Abstracts: J Develop Drugs

Abstract :

Green tea is a beverage that is popular worldwide. Polyphenols in green tea have been receiving attention for the maintenance of human health. The contribution of antioxidant activity in preventing diseases caused by oxidative stress has been focused upon. Hyperhomocysteinemia (Hhcy) is a risk factor for cardiovascular disease. The effects of Green Tea Extract (GTE) on isoprenaline (ISO)-induced Myocardial Infarction (MI) in hyperhomocysteinemic rats were studied. Hhcy resulted in significant blood pressure reduction, ST segment elevation and increase in heart rate, serum CK & LDH levels. Cardiac MDA was significantly increased, while GSH was decreased as compared to normal control group. All the previously mentioned parameters were significantly exaggerated in Hhcy rats treated with ISO as compared to Hhcy group. Administration of GTE during the induction of Hhcy showed a considerable reduction in serum markers of cardiotoxicity, heart rate, elevated ST segment and significant improve in the reduced blood pressure. Cardiac MDA was decreased while cardiac GSH was elevated. Hhcy+ISO caused disorganization of myocardial tissue which was restored in animals treated with GTE along with Hhcy+ISO. It can be concluded that GTE possesses an antioxidant activity and protect the heart from Hhcy alone or Hhcy+ISO induced MI. dr_azzaelmedany@yahoo.com