Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Lourdes DelRosso
Accepted Abstracts: J Clin Cell Immunol
The relationship between sleep and immunity has been well established. Cytokines have been demonstrated to both promote and inhibit REM sleep, hence viral and bacterial infections have different effects on our sleep patterns through immune related mechanisms. Sleep deprivation has been shown to affect immunity through altering the ratio of interleukin-6 and C-reactive protein (CRP); sleep excess has also been shown to elevate levels of CRP with concomitant increased risks in cardiovascular disease and diabetes. Interleukin-4 and tumor necrosis factor alpha have been found to be elevated in obstructive sleep apnea (OSA), while interleukin-10 is decreased. These changes have been hypothesized to play an intrinsic role in the pathophysiology of excessive sleepiness found in patients with OSA. Narcolepsy is another sleep disorder with significant immune pathophysiology. There is a strong association between narcolepsy and HLA DQB1*0602. Molecular mimicry, an immune response reaction, has been implicated in the cases of H1N1 vaccine -related narcolepsy. Other sleep disorders like insomnia and restless leg syndrome have also been linked to immune conditions. This presentation is intended to review the immune changes in sleep deprivation and the immunology related findings in the most common sleep disorders: OSA, narcolepsy, restless leg syndrome and insomnia.
Lourdes DelRosso completed her MD degree from University of Miami. She moved to California where she completed her Family Medicine Residency at Kaiser Permanente, a program affiliated to University of California Irvine. After 7 years in practice, she moved to Louisiana to train in sleep medicine under the direction of Dr. Andrew L. Chesson Jr. She joined the faculty at Louisiana State University School of Medicine. Since then she has published about 20 publications in reputed journals. She joined the Sleep Center at The Children?s Hospital Of Philadelphia in November 2013.