Journal of Antivirals & Antiretrovirals
Open Access

Impact of vancomycin monitoring on patient safety outcome

Joint Event on 4^th International Conference on Antimicrobials, Multiple Drug Resistance & Antibiotics Resistance & 4^thInternational Conference on Antibiotics R&D, B2B

April 20-21, 2018 Las Vegas, USA

Ali Mohammed Alkhodair

Prince Sultan Medical Military City, KSA

Posters & Accepted Abstracts: J Antivir Antiretrovir

Abstract :

Introduction: Vancomycin levels in the blood should be kept within a specific range to give the optimal antimicrobial killing and avoid resistance and toxicities. We aimed to evaluate the safety of vancomycin monitoring. Methods: This is a retrospective cohort study conducted at a single tertiary Prince Sultan Medical Military City, Riyadh, Saudi Arabia. The patients included were adults that were treated with vancomycin intravenously for more than 24 hours for suspected or proven infections. The primary outcome was the development of nephrotoxicity. Secondary outcomes included appropriate vancomycin initial dosing, sampling time, interpretation of vancomycin levels, and the development of other adverse reactions. Results: A total of 100 patients were enrolled in the study. Nephrotoxicity was identified to be about 3.8% (n=2). There was significant difference in the appropriateness of vancomycin initial dosing, sampling time, interpretation of vancomycin level, and other adverse reactions (P<0.001). Conclusion: Appropriate vancomycin initial dosing, sampling time, and interpretation of vancomycin levels are crucial aspects of vancomycin dosing and monitoring. alialkhodair@hotmail.com