Journal of Pharmaceutical Care & Health Systems
Open Access

In situ gelling Naltrexone hydrochloride films as a potential novel therapy for corneal healing disorders

European Pharma Congress

August 25-27, 2015 Valencia, Spain

Hamdy Abdelkader

Kingston University London, UK

Scientific Tracks Abstracts: J Pharma Care Health Sys

Abstract :

Corneal ulcers are common manifestations of a number of genetic (e.g. Familial corneal hypoesthesia), systemic (e.g. diabetes) and ocular (e.g. viral, drug toxicity and surgical) diseases. The standard treatment of corneal ulcers consists of a number of components including: maximizing preservative free topical lubricants, use of topical antibiotics and protecting the corneal surface with a bandage contact lens. However, even in combination these measures may be ineffective, and the outcome is often severe sight impairment. The aim of this study was to develop, characterize and clinically evaluate NTX in situ ocular films for effective and safe treatment of impaired corneal ulcers of different origins. The films were prepared from different amorphous polymers characterized for physicochemical compatibility, moisture-sorption, surface pH, mechanical properties, sterilisability, surface morphology, mucoadhesion, tolerability and accelerated stability at 40oC/75% relative humidity for 3 months. Glycerin (GLY)-plasticized films exhibited significantly better mechanical properties, compared with polyethylene glycol (PEG) 400 and triethylcitrate (TEC)-plasticized formulations.Superior mucoadhesion was recorded for F7 and F9 plasticized with GLY and PEG 400 respectively. The stability of NTX was significantly enhanced more than 18-times, compared with the solution form. Various corneal ulcers (atheromatous, viral and traumatic ulcers) were successfully treated and healed for a period not longer than 7 days, compared with several months for conventional therapy.

Biography :

Hamdy Abdelkader received his PhD from the School of Pharmacy, The University of Auckland, New Zealand in 2011. His PhD topic on surfactant-based vesicles (niosomes/discomes) for ocular delivery of the opioid growth factor receptor antagonist-Naltrexone Hydrochloride, where his research led to 8 peer-reviewed articles (5 original research articles + 3 review articles), in addition, he was awarded many international conference grants to USA, Europe and Australia. Hamdy has published over 20 scientific research publications (full research papers and conference abstracts). He started a Leverhulme research fellowship at Kingston University London in early 2014 and works with Prof. Barbara Pierscionek and Prof. Raid Alany. The current focus is on developing and optimizing a novel drug therapy for age-related ocular diseases of the anterior segment of the eye.

Email: H.Abdelkader@kingston.ac.uk