Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Mohsen Vigeh, Kazuhito Yokoyama, Takehisa Matsukawa, Atsuko Shinohara, Mamak Shariat and Katsumi Ohtani
AcceptedAbstracts: J Clinic Toxicol
L ead is toxic metal that can induce adverse effects on human mental development. To investigate the effects lead on pregnancy outcomes and children?s development, we have conducted a longitudinal study from 2007 to 2011 in Tehran, Iran. Apparently healthy pregnant women who referred to the research hospitals for prenatal care at first trimester of pregnancy (gestational age of 8-12 week) were asked to participate in the survey. Mothers? blood (one for each pregnancy trimester, i.e., 3 times) and umbilical cord blood samples were collected and subjected to ICP-MS analysis for measurement of lead concentration. We asked the mothers to come the hospitals when their children were at 18 to 36 months of age. Early Child Development Inventory was used to evaluate children?s development, which included 24 items about various sensory, immaturities, behavioral, hyperactively, and emotional problems. Mean lead levels for 1 st , 2 nd , and 3 rd trimesters in mother?s blood and in umbilical cord blood were 38.5, 34.5, 37.7, and 28.7μg/L, respectively. The mean score of developmental problem items was significantly correlated with the 2 nd and 3 rd trimester blood lead concentrations (r = 0.189 and 0.227, respectively; p value < 0.05). Increased blood lead concentrations during pregnancy, at the acceptable levels, may be a sensitive indicator of children?s developmental problems
Mohsen Vigeh obtained PhD degree in Social Medicine, the University of Tokyo, Japan. He completed medical doctorate course in Faculty of Medicine, Tehran University, Iran. He had been worked for Tehran University of Medical Sciences for several years and currently is senior scientific staff of the National Institute of Occupational Safety and Health, Japan. He collaborates with several local and overseas universities/institute and dose peer review for many medical/health journals. His research interest is ?reproductive toxicology?.