Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
+44 1478 350008
ISSN: 2161-1017
+44 1478 350008
Sandhya Rani Guggilla
Kakatiya University, India
Posters & Accepted Abstracts: Endocrinol Metab Syndr
For several reasons no two individuals can be considered identical and hence individualization of therapy is the current trend in treating the patients. Influence of menstrual cycle on the pharmacokinetics of Doxycycline. Twelve healthy female volunteers have been included in the study after obtaining written informed consent. The age ranged from 16 to 25 years. Experimental design: The volunteer selection and recruitment will be carried out after obtaining informed consent from each volunteer. The drug administration will be done to each volunteer at 7 a.m along with a glass of water after an overnight fasting on 3rd, 13th and 23rd day of menstrual cycle. These saliva samples will be stored under frozen conditions until HPLC analysis. Female sex hormones like estrogen,progesterone,follicle stimulating hormone,luetinising hormones,are estimated in blankblood sample in vijaya diagnostics. Results: In the present study the changes in estrogen levelsduring ovulatory phase have not shown any influence onAUCo-t of Doxycycline. Only AUCo-t of doxycycline showed an increasing trend with increasing levels of estrogen in ovulatary phase, but not in other phases. Eventhough the FSH levels differed significantly among volunteers during different phases FSH does not seem to influence overall pharmacokinetic behavior of Doxycyline during different phases. The present study indicated only the trend that the hormone levels may influence the pharmacokinetic behavior of the Doxycycline. Conclusion: In the present study the changes in hormones have shown an increasing C-max,increasing AUCo-t of Doxycycline pharmacokinetics significantly in follicular phase than ovulatory and luteal phases among volunteers during different phases.In other pharmacokinetic properties like clearance, biological haif life,volume of distribution,mean residence time the change was not significant.
Email: sandhyaguggilla9@gmail.com