Internal Medicine: Open Access
Open Access

Jagged-1 secreted by stromal cells mediated the different response of HSCs and HPCs to leukemic condition

2^nd International Conference on Internal Medicine & Hospital Medicine

September 13-14, 2017 Dallas, USA

Yizhuo Zhang, Chen Tian, Lina Wang, Chong Chen, Bing Xia, Qing Zhang, Tian Yuan, Yong Yu and Guoguang Zheng

Tianjin Medical University, China
Peking Union Medical College, China

Posters & Accepted Abstracts: Intern Med

Abstract :

Leukemia is the competition failure between normal and abnormal hematopoiesis. Our previous work found that in Notch1-induced murine T-ALL, normal HSCs were preserved in part because of increased mitotic quiescence of HSCs and resulted exhaustion of HPCs proliferation. The differential expression of Hes1 between HSCs and HPCs resulted in the distinct responses of these cells to the leukemic condition. But the mechanism of how leukemic environment affect the expression of Hes1 in normal HSC is still unknown. To elucidate the mechanism, upstream factors of Hes1 especially the cell surface receptor is detected. Also, the ligand and its origin cells are determined. The results find that Notch1 signaling pathway in normal HSCs is activated while it�¢����s silenced in normal HPCs. The adjacent cells around HSCs are stromal cells which secrete Jagged-1. Depletion of Jagged-1 will disrupt the balance between self-renew and proliferation of HSCs leading to their exhaustion. Our study will provide new ideas for the pathogenesis of leukemia, and provide a theoretical basis for the treatment of leukemia.