Gynecology & Obstetrics
Open Access

Landscape Genomics and Signature Selection to Understand the Genetic Adaptation of Indigenous Cattle

3^rd International Conference on Womens Health, Reproduction and Fertility

July 21, 2021 | Webinar

Filipa Sousa, Joana Oliveira, Ines Gante and Margarida Dias

Gynecology Departement Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal

Scientific Tracks Abstracts: Gynecol Obstet (Sunnyvale)

Abstract :

Introduction: Ovarian surgical ablation (OSA) in estrogen receptor-positive (ER+) breast cancer is usually performed to halt ovarian function in premenopausal patients. Since alternative pharmacological therapy exists and few studies have investigated why surgery is still performed, we aimed to analyze the reasons for the use of OSA despite the remaining controversy. Materials and Methods: Premenopausal ER+ breast cancer patients treated at a tertiary center (2005– 2011) were selected, and patients with germline mutations were excluded. Results: Seventy-nine patients met the inclusion criteria. Globally, the main reasons for OSA included: continued men- struation despite hormone therapy with or without ovarian medical ablation (OMA) (34.2%), pa- tient informed choice (31.6%), disease progression (16.5%), gynecological disease requiring sur- gery (13.9%), and tamoxifen intolerance/contraindication (3.8%). In women aged ≥45 years, patient choice was significantly more frequently the reason for OSA (47.4% versus 17.1% (p = 0.004)). For those aged <45 years, salvation attempts were significantly more frequent as compared to older women (26.8% versus 5.3% (p = 0.01)). In 77.8% of women undergoing OSA with menstrual cycle maintenance, surgery was performed 1–5 years after diagnosis, while surgery was performed earlier (0–3 months after diagnosis) in patients undergoing OSA as an informed choice (56.0%), as a salvation attempt (53.8%), or due to gynecological disease (63.6%). The leading reason for OSA in women previously undergoing OMA was continued menstruation (60.0%). Conclusions: This study suggests a possible failure of pharmacological ovarian suppression and reinforces the need for shared decisionmaking with patients when discussing treatment strategies, although valida- tion by further studies is warranted due to our limited sample size.

Biography :

Filipa Sousa completed her maters in the field of Contraception and Sexual and Reproductive Health, from University of Alcalá.