Journal of Glycobiology
Open Access
ISSN: 2168-958X
+44 1478 350008
ISSN: 2168-958X
+44 1478 350008
Cecilia H Marzabadi
Scientific Tracks Abstracts: J Glycobiol
We are interested in the synthesis and biological evaluation of new carbohydrate structures with the capacity to act as
immunomodulators. Towards these ends we have synthesized molecules as mimics of capsular saccharides. These highly
simplified saccharide structures have been shown to act as TLR4 agonists and to elicit the secretion of the proinflammatory
cytokines at concentrations lower than the known agonist, E. coli lipopolysaccharide. In this presentation, we will discuss the
synthetic efforts towards a lead compound and the preliminary biological data obtained for this compound. Efforts to elucidate
the mechanism of action of this molecule will be discussed in this presentation.
Cecilia H Marzabadi has completed her PhD at the University of Missouri-St. Louis and carried out her Postdoctoral studies at Hunter College- CUNY. She has been at Seton
Hall University for the past 15 years and has been a Visiting Professor at Harvard University Medical School and a Visiting Researcher at Memorial Sloan Kettering Cancer
Center. She has published numerous papers in the carbohydrate literature and currently serves as a Member at Large for the ACS Division of Carbohydrate Chemistry.