Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Matteo Micucci, Chiarini A and Budriesi R
University of Bologna, Italy
Scientific Tracks Abstracts: J Clin Toxicol
Several diseases with a high incidence including those pertaining cardiovascular system, are due to modifications of many molecular networks influencing each otherâ??s. The network based approach is based on the strategy named â??network target multi componentsâ? and â??network target single chemicalâ? strategies. In different traditional systems, including Traditional Chinese Medicine (TCM) and ayurveda, poly-herbal formulations are considered efficient approaches to the treatment of multifactorial diseases. Nutraceutical science is mainly aimed at identifying the chemical composition and the mechanisms of action of complex mixtures, including the vegetal extracts. In this study, we focused on primary hypertension, representing a multifactorial pathology strongly predisposing to cardiovascular events. Many vegetal extracts with antihypertensive activities modulate several targets determining multiple cardiovascular beneficial effects. Among others, extracts from Olea europaea L. leaves and Hibiscus sabdariffa L. flowers interfere with different pathways, producing a hypotensive activity. In this work, we evaluated the cardiovascular effects and the toxicological profile of a Nutraceutical Formulation (NF) based on a mixture of a Olea europaea L. leaves extract (OEE) and a Hibiscus sabdariffa L. flowers extract (HSE) in the ratio of 13:2 using in vitro biological assays. The NF exerted a vasorelaxant effect (IC50=2.38 mg/mL) and a negative chronotropic effect (IC50=1.04 mg/ mL) at concentrations lower than those producing smooth muscle spontaneous contractility alterations in the other organs. These experimental data suggest a potential application of this food supplement for contributing and managing preclinical hypertension.
Matteo Micucci completed his graduation in Pharmacy at Bologna University. In 2010, he worked in the laboratory of Dr. RRJ Arroo, Leicester School of Pharmacy, De Montfort University, UK. He was a Guest Scientist in the Department of Chemistry of Natural Substances, University of Naples “Federico II”, Italy. He awarded European PhD in Pharmaceutical Sciences at Bologna University in 2012. He is a Scientific Consultant, in the field of Nutraceutical, Alternative and Complementary Medicines, at Segreteria Particolare of a Senator of the Italian Republic. He is a Research Fellow Scientist at Department of Pharmacy and Biotechnology, University of Bologna.
Email: matteo.micucci2@unibo.it