Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Anti-Inflammatory effects of Tetrahydrocurcumin and calcium mineral crystalline: in vitro and in vivo study
Si Jun Park
Research and Development Center, ACT Co., Ltd., Republic of Korea
Posters & Accepted Abstracts: J Clin Exp Dermatol Res
Curcuma longa(Turmeric) has been used commonly as a spice, food additive, and an herbal medicine worldwide. This study aimed to investigate potential anti-inflammatory effect of Tetrahydrocurcumin (THC, extracted from Curcuma longa) with calcium mineral crystalline as vehicle. The THC assisted formation of biomineralized calcium mineral(THC & calcium mineral Complex) were synthesized via microemulsion. The potential anti-inflammatory effect of THC & calcium mineral Complex were examined by in vitro experiments. More specifically, THC & calcium mineral Complex decreased the expression levels of inflammatory effect, such has NO, MTT and PGE2 ELISA assay in Mouse macrophage. In addition, THC & calcium mineral Complex decreased the expression levels of inflammatory genes, such has cyclooxygenase-2 (COX-2), and interleukin-1-α (IL-1α) in keratinocytes. Clinical studies further suggested that treatment with formulations containing THC & calcium mineral Complex confers anti-inflamatory benefits. In the clinical study, the stable cream of water-in-oil emulsion containing the Complex improved human patch test, skin erythema value, and brightness significantly. Based on these results, we suggest that THC & calcium mineral Complex may be introduced as a possible anti-inflammatory agent and could be applicable to cosmetics as a functional(Useful) cosmetic ingredient.
Si Jun Park is currently working as an Senior researcher /Ph D in the R&D Center, ACT Co., Ltd., Republic of Korea. His research interest includes anti-aging effect, atopic dermatitis and treatment with carcium mineral particles as skin delivery system.
Email:jskim@actos.com