Journal of Clinical and Cellular Immunology
Open Access

Pro-inflammatory CCL3, 4 cytokines and B – follicular T cell interactions in the regulation of T-dependent humoral immune response

4^th International Conference and Exhibition on Immunology

September 28-30, 2015 Crowne Plaza Houston River Oaks, Houston, TX, USA

Irina Grigorova

University of Michigan Medical School, USA

Posters-Accepted Abstracts: J Clin Cell Immunol

Abstract :

B cell receptor crosslinking has been shown to induce production of proinflammatory chemokines CCL3/CCL4 in the native and germinal center (GC) B cells. Consistent with previous data we found that CCL3/4 expression in GC centrocytes is upregulated compared to native B cells and centroblasts. However, the role of CCL3/4 for GC B cell interactions with follicular T cells and the regulation of humoral immunity are poorly understood. We found that B cell intrinsic production of CCL3/4 is required for both their selection and control in GCs. In addition, intravital imaging analysis revealed that B-cell intrinsic production of CCL3/4 promotes GC B cell interactions with follicular regulatory and helper T cells. Further studies are under the way to address whether CCL3/4 forms local chemotactic gradients within GCs to promote recruitment of follicular T cells to a subset of GC B cells.

Biography :

Email: igrigor@umich.edu