Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
+44 1478 350008
ISSN: 2161-1017
+44 1478 350008
Lalit Kishore and Randhir Singh
M.M. University, India
Posters-Accepted Abstracts: Endocrinol Metab Syndr
Diabetic nephropathy is a long-term complication of diabetes mellitus. Chronic hyperglycemia leads to the generation of reactive oxygen species leading to oxidative stress. Oxidative stress along with hyperglycemia leads to the development of diabetic nephropathy. Bacopa monnieri is widely used in traditional medicine in India to treat various diseases like renal disorders, blood diseases, anemia, nerve tonic and poisoning. The present study was designed to evaluate alcohol extract of B. monnieri aerial parts in diabetic nephropathy in rats. Diabetic nephropathy was induced by intraperitoneal injection of streptozotocin (65 mg/kg) 15 min after Nicotinamide (230 mg/kg, i.p.) administration. Rats were divided into six groups (n=6). Group 1 and 2 were kept normal control and diabetic control respectively whereas Groups 3â��5 consist of diabetic nephropathy rats treated with different doses of extracts (100, 200 and 400 mg/kg) for 45 days. Glimipride (10 mg/kg) was used as standard. Diabetic nephropathy was assessed by determining serum glucose, urea, uric acid, creatinine level and tissue histological examination. Tissue antioxidant activity was assessed by measuring level of SOD, CAT, GSH, LPO. Alcohol extract of B. monnieri produced significant attenuation in the serum glucose level, uric acid, creatinine and lipid levels. Administration of extracts improves the level of SOD, CAT, GSH and decrease lipid peroxidation in terms of TBARS. Moreover histopathological examination also revealed the improvement in structural changes in nephrons and regeneration of �²-cells. So, it can be concluded that alcohol extract of B. monnieri produced protective effect by decreasing hyperglycemia, oxidative stress and improving the structural disarrangement in kidney of rats.
Email: lalitkishore000@gmail.com