Orthopedic & Muscular System: Current Research
Open Access

Role of X-chromosome encoded mirnas in autoimmunity: Suppressing the suppressor and female predisposition

2^nd International Conference and Exhibition on Orthopedics & Rheumatology

August 19-21, 2013 Embassy Suites Las Vegas, NV, USA

Anura Hewagama

Accepted Abstracts: Orthop Muscul Syst

Abstract :

R ole of skewed X inactivation may in part explain the high prevalence of autoimmune diseases in women. Human X chromosome encodes approximately 7% of the total microRNAs identified. Recent studies have implicated overexpression of X-linked miRNA in women affected by the autoimmune diseases. Potential biological targets of them include critically important genes such as FOXP3, CTLA-4, PDCD1 and, members of CBL and SOCS family ubiquitin ligases, which play an important role in the immune suppressive mechanisms and maintenance of tolerance. X-linked miRNA mediated post transcriptional suppression of immunosuppressive genes is an open area of study with potential to better understand why women develop many autoimmune disorders more often than men.