Journal of Proteomics & Bioinformatics
Open Access

Searching kinase-specific phosphoproteome for novel serum biomarkers

4^th International Conference on Proteomics & Bioinformatics

August 04-06, 2014 Hilton-Chicago/Northbrook, Chicago, USA

Achuth Padmanabhan

Accepted Abstracts: J Proteomics Bioinform

Abstract :

Serum biomarkers have the potential to serve as valuable tools in cancer diagnosis and prognosis. However, identifying potential candidates that would serve as robust biomarkers has been difficult. The abundance of serum Protein Kinase A (PKA) has been shown to vary during cancer progression. Although the molecular significance and function of PKA in the serum is unclear, following the dynamic status of serum PKA levels together with phosphorylation status of serum PKA substrates during cancer progression has the potential to accurately predict disease progression in patients. Here, we will review strategies to identify PKA substrates in the serum and determine their phosphorylation status during cancer progression. These studies will help uncover new serum biomarkers and also help unravel the role of extracellular PKA.

Biography :

Achuth Padmanabhan has completed his PhD from University of Maryland Baltimore County and is currently doing postdoctoral training from Yale University School of Medicine. He has published papers in reputed journals and also serves as an editorial board member of repute for many international journals.