Pediatrics & Therapeutics
Open Access
ISSN: 2161-0665
+44 1478 350008
ISSN: 2161-0665
+44 1478 350008
Rohit S Loomba
Medical College of Wisconsin, USA
Posters & Accepted Abstracts: Pediat Therapeut
Isomerism (also known as heterotaxy) is a unique condition which impacts 1 in 10,000 live births. Well recognized for the abnormalities in organ lateralization, isomerism is characterized by isomeric findings of the thoracic organs and random arrangement of the abdominal organs. Anatomic and functional abnormalities have been noted in every organ system although each individual patient may have a different number of affected organ systems with a variety of different findings possible in each organ system. Nearly all these children will have congenital heart disease, most of which will require single ventricle palliation. These children have gastrointestinal, immunologic, sinopulmonary and central nervous system issues which increase morbidity and mortality overall. Morbidity and mortality also increased during the perioperative and postoperative period in respect to cardiac surgery. It is thus imperative that cardiologists understand the nuances of isomerism to best manage these patients. While this is necessary, survey data collected by our group of nearly 200 pediatric cardiologists demonstrates that many do not understand the special considerations in respect to isomerism. This talk will discuss multisystem evaluation strategies in patients with isomerism as well as specific management strategies that can be employed to optimize outcomes and quality of life in these children. In addition, this talk will touch upon the underlying link of ciliary dyskinesia with isomerism and how this may be a therapeutic target to better manage these children as well. This talk will rely on data mostly from my research group which has been the most productive in respect to studying and publishing regarding isomerism (also known as heterotaxy).
Email: RLoomba@chw.org