Medicinal & Aromatic Plants

Medicinal & Aromatic Plants
Open Access

ISSN: 2167-0412

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Statement on benefit-risk relationship of Aconitum application based on the classical traditional Chinese medicine works


3rd Global Summit on Herbals & Traditional Medicine

October 18-20, 2017 Osaka, Japan

Zhang Xiao-Meng, Lin Zhijian and Zhang Bing

Beijing University of Chinese Medicine, China

Posters & Accepted Abstracts: Med Aromat Plants

Abstract :

The application of Aconitum herbs has a long history and wide range of indications, but in clinical, due to its inherent toxic ingredients, Aconitum herbs often lead to safety issues, whose application arouse public controversy. For the Aconitum herbs that have clear benefits and risks, how clinicians use? Therefore, based on retrieving more than 70 representative classical Traditional Chinese Medicine (TCM) works, such as Shennong's herbal, compendium of materia medica, treatise on febrile diseases and so on, we would systematically comb the benefit and risk cognition of Aconitum herbs by using the method of text mining, including the information of Aconitum��?s origin, toxicity, medication risk and pharmacovigilance, which can provide traditional reference for clinical benefit-risk assessment and reduce medication risk. In the classical TCM works, the cognization of toxicity of Aconitum herbs are almost accordance from ancient to present. Radix Aconitum carmichaelii (Chuanwu) and Radix Aconitum kusnezoffii (Caowu) have strong toxicity, while Radix Aconitum carmichaelii (Fuzi) has toxicity. The medication risk of Aconitum herbs is not only relative with its own property, but also affected by processing, pattern, compatibility, dosage, patient physique and so on. How these factors influence the benefit-risk relationship of Aconitum application are presented. From the representative classical medical formularies, we retrieved 7357 prescriptions (8.62%) that containing Aconitum herbs, whose medication ratio was relatively high. Ancient clinicians can effectively reduce the medication risk and ensure the efficacy of Aconitum herbs by alerting the risk factors in the medication course. At the same time, the classical works also recorded a lot of methods to detoxicate Aconitum toxicity, which major are cold, sweet drugs or foods. All in a word, although Aconitum herbs are with toxicity, the risk of toxicity-effect of Aconitum clinical used can be controlled if alerting various application factors.

Biography :

Zhang Xiao-Meng is currently pursuing PhD in Clinical Pharmacy at Beijing University of Chinese Medicine. She has her expertise in pharmacovigilance and rational use of traditional Chinese medicine. She has published 3 SCI papers and 4 papers in core periodicals.

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