Journal of Glycobiology
Open Access

Structural studies of vaccine target outer membrane proteins from pathogenic bacteria

Glycobiology World Congress

August 10-12, 2015 Philadelphia, USA

Mikio Tanabe

Posters-Accepted Abstracts: J Glycobiol

Abstract :

Bacterial porins are major outer membrane proteins that function as essential solute transporters such as sugars, ions and
wastes between the bacteria and the extracellular environment but also recognized as potential vaccine target. The structural
features of porins are also recognized by eukaryotic cell receptors involved in innate and adaptive immunity. We have studied
three major porins from pathogenic bacteria, the OmpP2 (P2) from Haemophilus influenzae, FomA from Fusobacterium
nucleatum and PorB from Neisseria meningitides. They have unique solute transport activity with size exclusion limit. I will
also present the latest results of our studies of porins in the meeting.