Organic Chemistry: Current Research
Open Access
ISSN: 2161-0401
+44 1478 350008
ISSN: 2161-0401
+44 1478 350008
Gurvinder Singh
Punjab Technical University, India
Posters & Accepted Abstracts: Organic Chem Curr Res
Benzoxazoles are a large chemical family used as antimicrobial agents against a wide spectrum of microorganisms. The high therapeutic activity of the related drugs has encouraged the medicinal chemists to synthesize a large number of novel chemotherapeutic agents. The reaction of 2-aminophenol and p-amino benzoic acid yielded 2-(4-aminophenyl)benzoxazole in the presence of polyphosphoric acid which was further condensed with different aromatic aldehydes offered Schiff bases. The compounds were synthesized in good yield and the chemical structures of the compounds were elucidated by their TLC, IR and 1HNMR. Their antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and antifungal activity against Aspergillus niger, Candida albicans were investigated. The results showed that all of the newly synthesized compounds (G-2- to G-8) have exhibited significant antimicrobial activity.