Journal of Pharmaceutical Care & Health Systems
Open Access

Synthesis, molecular docking and biological activity of novel C3 substituted 1, 4-benzodiazepine derivatives as CCKA receptor antagonist

6^th Asia-Pacific Pharma Congress

July 11-13, 2016 Kuala Lumpur, Malaysia

Sumitra Nain, Dharma Kishore, Swapnil Sharma and Sarvesh Paliwal

Banasthali University, India

Posters & Accepted Abstracts: J Pharma Care Health Sys

Abstract :

Cholecystokinin (CCK) has been found to play a major physiological role in the regulation of gastrointestinal (GI) motility by acting on CCKA & CCKB receptor. Among CCKA and CCKB, CCKA receptors are mainly localized on pancreas, gallbladder, pylorus, intestine and the vagus nerve. In this present research work we have made an effort to design and synthesize C3 substituted 1, 4 benzodiazepines. As a first screen all the synthesized compounds were subjected to molecular docking. This led to the identification of five potential CCKA receptor antagonists. All the five compounds evaluated for their CCKA antagonist activity by in vitro rat ileum motility model. The compound IV, III showed significant CCKA antagonist activity.

Biography :

Email: nainsumitra@gmail.com