Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Marc-Alexander Ohlow
Central Clinic Bad Berka, Germany
Keynote: J Clin Exp Cardiolog
Background & Aim: Cardiac autoantibodies have been detected among patients suffering from Dilated Cardiomyopathy (DCM). Elimination of these antibodies by immune-adsorption (IA) may lead to functional improvement due to enhanced cardiac function at echocardiography. Aim of this prospective cohort study was to evaluate outcomes in patients with DCM undergoing IA. Methods: Consecutive patients undergoing IA in 5 consecutive days followed by IgG substitution were included. Echocardiographic and clinical parameters were assessed at baseline (BL) and 12 months follow-up (FU). Response to IA was defined as achievement of ΓΆΒ?Β¥2 of the following parameters: Improvement of symptoms (decrease of ΓΆΒ?Β¥1 NYHA class), increase of left ventricular (LV) ejection fraction (EF) ΓΆΒ?Β¥10% or Minnesota Heart Failure Questionnaire (MLHFQ) ΓΆΒ?Β¥5 points, decrease of LV end-diastolic dimension (EDD) ΓΆΒ?Β¥10% or NT-pro-BNP ΓΆΒ?Β¥50%. Results: 93 patients (median age 61 years, LVEF 30%, duration of symptoms 14 months, 87% of patients in NYHA class III/IV) were studied. In 70 (75%) patients results of an endomyocardial biopsy (EMB) results were available. Four (5.4%) patients were lost to FU and the complication rate of IA was 17.2% (n=16). A significant improvement of NYHA-Class (median 3.0 versus 2.0), LV-EF (30% versus 38%), LVEDD (62 versus 59 mm), NT-pro-BNP (892 versus 523 pg/ml) and scoring of the MLHFQ (50 versus 26 points) was be observed at FU (p<0.05 for all). After IA, 48% (n=43) of patients were classified as responders and they were characterized by a shorter disease duration (14 versus 22 months), larger BL LVEDD (64 versus 60 mm), presence of >1 viral genome and higher values of activated T-cells at EMB. Conclusion: IA significantly improves echocardiographic and clinical parameters in patients with DCM.
Marc-Alexander Ohlow is currently an Adjunct Professor of Cardiology and Vice-Director Cardiology Department Zentralklinik Bad Berka. He is a board certified Specialist in Emergency Medicine, Interventional Cardiology, Lipidology and Heart Rhythm Device Implantation. His research interests are interventional cardiology, structural heart disease, heart rhythm device implantation and inflammatory cardiomyopathy. He has >70 published papers in peer-reviewed national/international journals including European Heart Journal, JACC, JACC Interventions, Circulation Interventions, Europace and International Journal of Cardiology. He is also the Member of the Editorial Board of the Journal of Geriatric Cardiology.
Email:mago-weimar@gmx.de