Anesthesia & Clinical Research
Open Access

Chuixian Zhou

Publications

• Research Article
  Dexmedetomidine versus Midazolam as Premedication in Anesthesia: A Meta-Analysis from Randomized Controlled Clinical Trials
  Author(s): Chuixian Zhou and Junhui ZhaoChuixian Zhou and Junhui Zhao
  
  Dexmedetomidine [Dex] is an α2-adrenoceptor agonist which provides sedation, analgesia and anxiolytic effects, thus making it a potentially useful anesthetic premedication. A number of clinical trials have been conducted to compare the sedative effect of Dex versus midazolam [Mdz], a conventional sedative agent in anesthesia. Nevertheless, consensus has not been achieved on which agent is superior to the other in terms of the overall benefit to patients. In this study, we have isolated four independent studies containing randomized, controlled, clinical trials on patients and compare the efficacy and safety of these two agents as a premedication in anesthesia. In the studies of the catheter ablation of atrial fibrillation and surgical correction of scoliosis deformities, Dex treatment resulted in a better sedative and analgesic effects, reflected by a reduced pain, a lower dose .. View More»
  DOI: 10.4172/2155-6148.1000457

  Abstract PDF

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