Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Luiz H. Lima
Brazil
Research Article
Functional Analysis of Retinal Flecks in Stargardt Disease
Author(s): Tommaso Verdina, Stephen H. Tsang, Vivienne C. Greenstein, Jana Zernant, Andrea Sodi, Luiz H. Lima, Stanley Chang, Rando Allikmets and Ugo MenchiniTommaso Verdina, Stephen H. Tsang, Vivienne C. Greenstein, Jana Zernant, Andrea Sodi, Luiz H. Lima, Stanley Chang, Rando Allikmets and Ugo Menchini
Purpose: To evaluate visual function of flecked areas in a series of patients with Stargardt disease (STGD) and compare them with adjacent non flecked areas. Methods: Twenty–seven patients with STGD, ABCA4 mutations and yellowish retinal flecks at fundus examination were recruited. Microperimetry with the Nidek MP-1 and fundus autofluorescence imaging (FAF) were performed in all the patients (27 eyes) while spectral-domain optical coherence tomography (SD-OCT) was performed in a subgroup of patients (20 eyes). Visual sensitivity (in dB) for each hyperfluorescent flecked area on FAF was compared with the value of the nearest adjacent non-flecked area in the MP-1 grid and at approximately the same distance from the fovea. Retinal structure in some of the flecked areas tested by microperimetry was analysed with SD-OCT. All patients were scree.. View More»
DOI:
10.4172/2155-9570.1000233