Journal of Clinical and Cellular Immunology
Open Access

Shikhar Mehrotra

Publications

• Review Article
  Apoptosis – an Ubiquitous T cell Immunomodulator
  Author(s): Anuradha K. Murali and Shikhar MehrotraAnuradha K. Murali and Shikhar Mehrotra
  
  Apoptosis is a natural process where cells that are no longer required can be eliminated in a highly regulated, controlled manner. Apoptosis is important in maintaining the mammalian immune system and plays a significant role in immune response, positive and negative T cell selection, and cytotoxic death of target cells. When the apoptotic pathways are impaired or are not tightly regulated, autoimmune diseases, inflammatory diseases, viral and bacterial infections and cancers ensue. An imbalance in the anti-apoptotic and pro-apoptotic factors has been implicated in these diseases. Moreover, current therapies directed towards these diseases focus on the modulation of the apoptotic death pathways to regulate the immune response. In this review, we will focus on the process of T cell activation and apoptosis in autoimmune reactions, in response to tumor progression as well as in response.. View More»
  DOI: 10.4172/2155-9899.S3-002

  Abstract PDF

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