Journal of Chromatography & Separation Techniques
Open Access

Keyur B.Ahir

Publications

• Research Article
  Development of a Validated Stability- Indicating HPTLC Method for Nitazoxanide in Pharmaceutical Formulation
  Author(s): Keyur B.Ahir, Emanuel M. Patelia and Falgun A.Mehta Keyur B.Ahir, Emanuel M. Patelia and Falgun A.Mehta
  
  The present paper describes stability indicating high-performance thin-layer chromatography (HPTLC) assay method for nitazoxanide in bulk drugs. The method employed TLC aluminium plates precoated with silica gel 60F-254 as the stationary phase. The solvent system consisted of carbon tetra chloride: ethyl acetate (7:3 v/v). The system was found to give compact spot for nitazoxanide (Rf value of ± 0.02). Densitometric analysis of nitazoxanide was carried out in the absorbance mode at 345 nm. The linear regression analysis data for the calibration plots showed good linear relationship with r2 = 0.9992 ± 0.0001 with respect to peak area in the concentration range 200 - 1200 ng spot-1. The mean value ± S.D. of slope and intercept were 9.3726 ± 0.023 and 3795.46 ± 13.940 with respect to peak area. The developed HPTLC method was validated with respect to ac.. View More»
  DOI: 10.4172/2157-7064.1000138

  Abstract PDF

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