Fungal Genomics & Biology
Open Access
ISSN: 2165-8056
ISSN: 2165-8056
Bernardino MC
Brazil
Mini Review
Glucosylceramides from Pseudallescheria/Scedosporium Complex
Author(s): Rollin-Pinheiro R, Meirelles JV, Bernardino MC and Barreto-Bergter ERollin-Pinheiro R, Meirelles JV, Bernardino MC and Barreto-Bergter E
Pseudallescheria/Scedosporium species are filamentous fungi widely distributed in nature. Some are considered emerging pathogen due to its clinical importance, especially in immunocompromised patients. During the last few years, many virulence factors have been described, some of them being molecules localized on the fungal cell wall, such as glycoproteins, polysaccharides and glycolipids. In this context, one glycosphingolipid specifically, glucosylceramide (GlcCer), has been chemically identified and its biological roles have been described. GlcCer is a conserved structure in the Pseudallescheria/Scedosporium complex and also in other fungal species. In addition, it plays important roles in fungal growth and differentiation, host-pathogen interaction, immune response modulation and it has been considering a potential target for new antifungal drugs. The use of monoclonal antibodies .. View More»
DOI:
10.4172/2165-8056.1000147