Journal of Proteomics & Bioinformatics
Open Access

James Lyons-Weiler

Publications

• Research Article
  Optimization of the Use of Consensus Methods for the Detection and Putative Identification of Peptides via Mass-spectrometry Using Protein Standard Mixtures
  Author(s): Tamanna Sultana, Rick Jordan, James Lyons-WeilerTamanna Sultana, Rick Jordan, James Lyons-Weiler
  
  Correct identification of peptides and proteins in complex biological samples from proteomic mass-spec tra is a challenging problem in bioinformatics. The sensit ivity and specificity of identification algorithms depend on underlying scoring methods, some being more sensiti ve, and others more specific. F or high-throughput, auto- mated peptide identification, control over the algo rithm s performance in terms of trade-off between s ensitivity and specificity is desirable. Combinations of algorithms, called ‘consensus meth ods’, have been shown to pro- vide more accurate results than individual algorith ms. However, due to the proliferation of algorithms and their varied internal settings, a systematic understandin g of relative performance of individual and consens us meth- ods.. View More»
  DOI: 10.4172/jpb.1000085

  Abstract PDF

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