Journal of Clinical & Experimental Dermatology Research
Open Access

Malvehy J

Publications

• Research Article
  Field Cancerisation Improvement with Topical Application of a Film-Forming Medical Device Containing Photolyase and UV Filters in Patients with Actinic Keratosis, a Pilot Study
  Author(s): Susana Puig, Puig-Butillé JA, Díaz MA, Trullas C and Malvehy JSusana Puig, Puig-Butillé JA, Díaz MA, Trullas C and Malvehy J
  
  Background: Actinic keratoses (AKs) are considered to be a ‘field of cancerization’ consisting of a histologically abnormal epithelium adjacent to tumour tissue. Treatment of the ‘field of canceri-zation’ is important for the prevention of neoplasm progression. UV radiation, especially UVB, produce genotoxic photoproducts such as cyclobutane pyrimidine dimers (CPDs) and 6-4 photo-products (6-4PPs) in DNA, being major players in skin cancerization. The potential use of DNA photolyases in skin cancer prevention is increasingly being demonstrated. Topical application of a liposome formulation containing CPD photolyase onto human skin provides protection against UV-B-induced damages. Objectives: To assess the effects of topical application of a medical device (Eryf-AK) containing a DNA-repair enzyme, photolyase, encapsulate.. View More»
  DOI: 10.4172/2155-9554.1000220

  Abstract PDF

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